Researcher Publications

A multidimensional platform to support intestinal epithelial and immune cell co-culture, Jennifer L. Walker, Melissa Sprachman, Elizabeth Wielette, et al

Mapping histologic and functional maturation of human endocrine pancreas across early postnatal periods, Diane C. Saunders, Fan Feng, Marcela Brissova, et al

Integrated multiomic analysis identifies TRIP13 as a mediator of alveolar epithelial type II cell dysfunction in idiopathic pulmonary fibrosis, Laurence St. Pierre, Asres Berhan, Zea Borok, et al.

Formation of functionally robust human neocartilage from multiple donors using highly expanded costochondral cells, Takumi Takahashi, Wendy E Brown, Cecilia T Trinh, Jerry C Hu and Kyriacos A Athanasiou

MYL4 Identifies Intramural Anatomy of Purkinje Fibers in Human Hearts, Matthew L. Hillestad, Matthew Amontree, Atta Behfar, et al.

Disease modifying osteoarthritis drug discovery using a temporal phenotypic reporter in 3D aggregates of primary human chondrocytes, Cruz MA, Gronowicz S, Karimzadeh M, Martyniak K, Medam R, Kean TJ.

The Fibrotic Phenotype of Human Precision-Cut Lung Slices Is Maintained after Cryopreservation. Institute for In Vitro Sciences, Inc. Méry Marimoutou, VJae Hun Kim, Niccole Schaible, Jose Alvarez, et al.

Quantification of follicles in human ovarian tissue using image processing software and trained artificial intelligence. University of Michigan, Dept.of Ob/Gyn. GM Blevins, CL Flanagan, SS Kallakuri, OM Meyer, L Nimmagadda, …

Cellular atlas of the human ovary using morphologically guided spatial transcriptomics and single-cell sequencing. University of Michigan, Dept.of Ob/Gyn. ASK Jones, DF Hannum, JH Machlin, A Tan, Q Ma, ND Ulrich, Y Shen, …

Biomarkers of exposure in human proximal tubular cells incubated with nephrotoxic environmental chemicals and drugs: Altered metabolic pathways. Wayne State University School of Medicine. L.H. Lash, P. Mathieu, X. Hu, D.P. Jones, P.M. Stemmer, and R. Rosati.

Inflammatory and hypoxic stress-induced islet exosomes released during isolation are associated with poor transplant outcomes in islet autotransplantation. Virginia Commonwealth University. Prathab Balaji Saravanan, Jagan Kalivarathan, Kaeden McClintock, Shujauddin Mohammed, Elijah Burch, Christiane Morecock, Jinze Liu, Aamir Khan, Marlon F. Levy, Mazhar A. Kanak

Common pathways in human proximal tubular cells altered by exposures to diverse environmental agents and nephrotoxic therapeutic drugs. Wayne State University School of Medicine. L.H. Lash, P. Mathieu, R. Rosati, P.M. Stemmer, X. Hu, and D.P. Jones.

Cryopreserved human precision-cut lung slices provide an immune competent pulmonary test system for “on-demand” use and long-term cultures. Institute for InVitro Biosciences, Inc. Vivek S. Patel, Khalid Amin, Adam Wahab Mery Marimoutou, Lindsey Ukishima, Jose Alvarez, Kelley Battle, Andreas O. Stucki, Amy J. Clippinger, Holger P. Behrsing

Multiscale stiffness of human emphysematous precision cut lung slices. Institute for InVitro Biosciences, Inc. Jae Hun Kim, Niccole Schaible, Joseph K. Hall, Erzsébet Bartolák-Suki, Yuqing Deng, Jacob Herrmann, Adam Sonnenberg, Holger P. Behrsing, Kenneth R. Lutchen, Ramaswamy Krishnan, Béla Suki

Chronic superphysiologic AMH promotes premature luteinization of antral follicles in human ovarian xenografts. Limor Man, Nicole Lustgarten Guahmich, Eleni Kallinos, Barbara Caiazza, Monica Khan, Zong-Ying Liu, Ritaben Patel, Carmen Torres, David Pepin, …, Daylon James.

Human ovarian follicles xenografted in immunoisolating capsules survive long term implantation in mice. University of Michigan, Dept.of Ob/Gyn. MA Brunette, HM Kinnear, PH Hashim, CL Flanagan, JR Day, M Cascalho, …

Cellular heterogeneity of human fallopian tubes in normal and hydrosalpinx disease states identified using scRNA-seq. University of Michigan, Dept.of Ob/Gyn. ND Ulrich, Y Shen, Q Ma, K Yang, DF Hannum, A Jones, J Machlin, …

Cellular biomarkers of renal injury. Wayne State University School of Medicine. L.H. Lash

Secreted proteins, lipids and low-molecular-weight metabolites as early biomarkers of human proximal tubular cell exposure to nephrotoxic agents. Wayne State University School of Medicine. L.H. Lash, P. Mathieu, P.M. Stemmer, R. Rosati, X. Hu, and D.P. Jones

Secreted proteins, lipids and low-molecular-weight metabolites as early biomarkers of human proximal tubular cell exposure to nephrotoxic agents. Wayne State University School of Medicine. L.H. Lash, P. Mathieu, P.M. Stemmer, R. Rosati, X. Hu, and D.P. Jones.

Estimating Nephron Number from Biopsies: Impact on Clinical Studies. Washington University School of Medicine. Darya Morozov, Neda Parvin Mark Conaway, Gavin Oxley, Edwin J. Baldelomar, et al,

Diverse roles of mitochondria in renal injury from environmental toxicants and therapeutic drugs. Wayne State University School of Medicine. L.H. Lash

Renal Mitochondria as Sentinels for Exposures to Environmental Toxicants and Nephrotoxic Drugs. Wayne State University School of Medicine. L.H. Lash, P.M. Stemmer

Mapping kidney tubule diameter ex vivo by diffusion MRI. Washington University School of Medicine. Darya Morozov,1 Neda Parvin,1 Jennifer R. Charlton,2 and Kevin M. Bennett1.

Image analysis techniques to map pyramids, pyramid structure, glomerular distribution, and pathology in the intact human kidney from 3-D MRI. Washington University School of Medicine. Jennifer R. Charlton, Yanzhe Xu, Neda Parvin Teresa Wu, Fei Gao, et. al.

Enhanced method to select human oogonial stem cells for fertility research. Wake Forest University. Russel C. Sequeira, Sivanandane Sittadjody, Tracy Criswell, Anthony Atala, John D. Jackson, James J. Yoo

Comparison of Long-term Human Precision-cut Lung Slice Culture Methodology and Response to Challenge: An Argument for Standardisation. Institute for InVitro Biosciences, Inc. Vivek Patel, Khalid Amin, David Allen, Lindsey Ukishima, Adam Wahab, Chad Grodi1 and Holger Behrsing

Development of Ectopic Livers by Hepatocyte Transplantation Into Swine Lymph Nodes. LyGenesis. Paulo Fontes , Junji Komori ,Roberto Lopez , Wallis Marsh, Eric Lagasse

Ex Vivo Cell Therapy by Ectopic Hepatocyte Transplantation Treats the Porcine Tyrosinemia Model of Acute Liver Failure. LyGenesis. Clara T. Nicolas, Robert A. Kaiser, Raymond D. Hickey , Kari L. Allen Zeji Du, Caitlin J. VanLith, et al.

Defective Fibrillar Collagen Organization by Fibroblasts Contributes to Airway Remodeling in Asthma. Leila B. Mostaço-Guidolin, Emmanuel T. Osei, … David Walker and Tillie-Louise Hackett

Kidney-in-a-lymph node: A novel organogenesis assay to model human renal development and test nephron progenitor cell fates. LyGenesis. Maria Giovanna Francipane, Bing Han, Leif Oxburgh, Sunder Sims-Lucas, Zhongwei Li, Eric Lagasse

Human islets expressing HNF1A variant have defective ß cell transcriptional regulatory networks. Rachana Haliyur, …, Marcela Brissova, Alvin C. Powers

Optimization of Laser Capture Microdissection for Isolation of Enteric Ganglia from Fresh Frozen Human Tissue. Aaron May-Zhang, Karen Deal, Michelle Southard-Smith

Sara Manti, Terri J Harford, Carmelo Salpietro, FaribaRezaee, Giovanni Piedimonte, Induction of high mobility group box-1 in vitroand in vivo by respiratory syncytial virus

Transporter-dependent cytotoxicity of antiviral drugs in primary cultures of human proximal tubular cells, Lawrence H. Lash, Caroline A. Lee, Clynn Wilker, Vishal Shah

A Comparison of Adult and Neonatal Human Hepatocytes in Drug Metabolizing Enzyme Activities

Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors.

Prostaglandin D2 and the role of the DP1, DP2 and TP receptors in the control of airway reflex events

Tiotropium modulates transient receptor potential V1 (TRPV1) in airway sensory nerves: A beneficial off-target effect?

Multigenerational Study of Chemically Induced Cytotoxicity and Proliferation in Cultures of Human Proximal Tubular Cells

MRI-Based Glomerular Morphology and Pathology in Whole Human Kidneys

Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin

Lethal Toxin Reduces Human Alveolar Epithelial Barrier Function

Influenza Virus Suppresses RIG-I Initiated Innate Antiviral Responses in Human Lung

Pharmacologic Specificity of Nicotinic Receptor-Mediated Relaxation of Muscarinic Receptor Precontracted Human Gastric Clasp and Sling Muscle Fibers within the Gastroesophageal Junction

Quantitation of the Contractile Response Mediated by Two Receptors: M2 and M3 Muscarinic Receptor-Mediated Contractions of Human Gastroesophageal Smooth Muscle

Role of mitochondrial dysfunction in cellular responses to S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells

Characterization of Side Population Cells from Human Airway Epithelium

Utilization of a test gradient enhances islet recovery from deceased donor pancreases

Experimental Validation of a Finite Element Model of a Human Cadaveric Tibia

Subject-specific finite element models implementing a maximum principal strain criterion are able to estimate failure risk and fracture location on human femurs tested in vitro

Differentiated Human Alveolar Epithelial Cells and Reversibility of their Phenotype In Vitro

Subject-specific finite element models can accurately predict strain levels in long bones

In vitro replication of spontaneous fractures of the proximal human femur

In vitro method for assessing femoral implant–bone micromotions in resurfacing hip implants under different loading conditions

Wilson S, Patnaude L, Sharon M, et al, Development of a Preclinical Human Colon Explant Model that Recapitulates Physiological Hallmarks of Inflammatory Bowel Disease and Can be Used to Support Drug Discovery, May 3-6, 2025, San Diego, CA

Development of a Rapid, Temporal, Cartilage Assay to Screen Novel Arthritis Therapeutics, Vijayakumar J, Kean TJ, April 7-9 2025; Pittsburg, PA.